cure for parkinson's disease 2020

In addition, we must remember that a clinical trial is supposed to be an unbiased evaluation of a treatment. A clinical trial of Nicotinamide Riboside (a form of Vitamin B3) has started in Norway – it is called the ‘NOPARK’ Study. In addition, there is evidence that the drug also blocks the aggregation of alpha synuclein and has beneficial effects in models of Parkinson’s (Click here to read an example). This study is expected to finish in early 2021. This biotech firm is developing a cell-permeable form of PARKIN (iCP-Parkin), which has been reported to promote preservation of dopamine neurons in models of Parkinson’s (Click here to read more about this). In addition to these passive immunotherapy treatments, there are also two companies that are testing active immunotherapy treatment in Parkinson’s. The beauty of this meeting is that it is a two for one deal – while there are scientific research lectures on one side of the conference center, at the same time there is the Rallying to the Challenge meeting being held on the other side. Price on request Parkinsons Disease Treatment View details & Read reviews CALL NOW ENQUIRE NOW . The Ambroxol post will have to wait a few days I’m afraid, bit too busy on this end, but this is a good summary of the results: https://www.cureparkinsons.org.uk/news/ambroxol-phase-ll-results-published A large Phase III clinical trial of the effects of Lingzhi (also known as Ganoderma or reishi in Japan) on disease progression in 288 people with recently diagnosed, untreated Parkinson’s is scheduled to finish in late 2020 (Click here to read more about this study). Recently there has been a series of studies suggesting that plasma – the portion of blood that doesn’t contain cells – from young organisms may contain beneficial properties for older organisms. Ambroxol is a commonly used treatment for respiratory diseases. Two of these trials are scheduled to finish in 2020. They recently were awarded a grant from the Michael J Fox Foundation to take their drug forward (Click here to read the press release). As part of that deal, GSK is contributing its LRRK2 inhibitor program, and they may be hoping to use 23andMe’s database of people who know their LRRK2 genetic status. Fox Foundation's annual scientific conference and the only one in the world focused exclusively on Parkinson's disease drug development. The first c-Abl inhibitor to be clinically tested in Parkinson’s was Nilotinib and some of the results were made available in late 2019. One of the more novel alpha synuclein-targted approaches for Parkinson’s is being clinically tested by the biotech company Yumanity. PARKIN is a protein that has many functions, and disruption of it is associated with increased risk of developing Parkinson’s. Now scientists are searching for a way to replace these nerve cells. A clinical trial in Taiwan investigating the statin Lovastatin as a neuroprotective treatment for early stage Parkinson’s was scheduled to finish in late 2019 (Click here to read more about this study), so we may see those results in 2020. Prof Schweitzer has published some work in the field of cell therapy for Parkinson’s (for example, https://www.jci.org/articles/view/130767 ), he speaks English, French and Mandarin Chinese, and it will be interesting to watch what happens in Boston with their research. Please understand that there is still a long way to go for all of these experimental therapies. There are no cell therapy approaches for Parkinson’s that have been approved by any medical regulators. Both pain and PD conditions cause cortical excitability reduction, but mental representations techniques are thought to be able to counteract it, resulting also effective in chronic pain conditions. The results of the Phase I RASMET study have been published (Click here to read them and click here to read the press release), and the company is currently conducting a Phase IIa ‘KARMET’ clinical study of ENT-01, which is scheduled to finish in October 2020 (Click here to read more about this study). In 2019, we saw the publication of the Bristol Phase II GDNF clinical trial results. This gene produces an enzyme (called Glucocerebrosidase) that breaks down specific proteins. Change ), You are commenting using your Facebook account. In fact, there are some cases of Parkinson’s that do not involve any accumulation of alpha synuclein at all. We will be interested to learn of new developments from both companies in 2020. One inflammation-related biotech company that we are watching in 2020 is Inmune Bio. Source: Utahscouts. But there has been the hint of a potential neuroprotective effect in one class of drugs for Parkinson’s: GLP-1R agonists. Other c-Abl inhibitors are being developed for neurological conditions, chief among these for Parkinson’s is K0706, which is being developed by Sun Pharma Advanced Research Company (or SPARC). Before we finish (yes, there is still more! And finally, it will be interesting to learn in 2020 what has developed from the Servier and Oncodesign collaboration to develop novel LRRK2 inhibitors (Click here to read more about this). Register for the 2020 HPA Walk Register Now. The exact cause of Parkinson’s disease is unknown. While there are treatments to alleviate symptoms of Parkinson's disease, there is no known cure or preventive drug. Most of patients can have normal life as long as following the right protocol. This is a phase II, 52 week trial of Ambroxol in 75 people with Parkinson’s Disease Dementia (Click here to read more about this trial). Feb. 27 (UPI) --Researchers have developed a new drug that could correct damage to the brain caused by Parkinson's disease and lead to improvement … An example of an iron chelator is a drug called Deferiprone, and there have recently been two large Phase II clinical trials assessing this approach in Parkinson’s. Following evidence suggesting beneficial effects in models of Parkinson’s and a small open label Phase I pilot study (Click here to read more about this), two larger double-blind clinical trials were initiated: PD Nilotinib and NiloPD. Publication date: Dec 03, 2020. New Developments In Diabetes Drugs for Parkinson's - January 2020 At the forefront of treatments for diabetes is a class of drug called glucagon-like peptide 1 receptor (GLP-1R) agonists. This meeting “will focus on the origins and development of Parkinson’s, from potential triggers through the early symptoms and stages of the disease“. In 2019, another Korean pharmaceutical company Dong-A ST Co was scheduled to complete a Phase II clinical trial of DA-9805 in people with Parkinson’s (Click here to read more about this trial). Prof. Anumantha Kanthasamy says Parkinson’s is particularly hard to diagnose and doctors often misdiagnose it early on. In 2020, I will be curious to see if companies like Fujifilm/Cellular Dynamics or Novo Nordisk step up to the plate and start a clinical trial program focused on cell transplantation for Parkinson’s. These are two meetings that I can thoroughly recommend to readers who have never attended such an event. Prof Englund and colleagues have recently been awarded a Michael J Fox foundation research grant to further develop this line of research (Click here to read more about this). I would be remise if I did not make one last statement regarding the need to check expectations. Limited preclinical research has been published in the west with this extract of an oriental fungus in models of Parkinson’s (for examples, click here and here), but the results of this clinical trial could be something to keep an eye out for in 2020. A biotech firm called Annovis (formerly QR Pharma) are currently clinically testing ANVS-401 (also known as Posiphen) in Alzheimer’s (Click here to read more about that clinical trial). FAF1 is a protein involved with cell death, so by inhibiting/blocking it the researchers are investigating whether this could be beneficial in Parkinson’s. This study is a randomised, double-blind trial involving 200 participants with newly diagnosed Parkinson’s, who will be randomly assigned in an 1:1 ratio to either nicotinamide riboside or placebo treatment for 52 weeks. I hope all is well. In 2020, we will also be looking for news from a biotech firm called Prevail Therapeutics. And by limiting the build up of proteins – like alpha synuclein – these experimental therapies may help to slow down the progression of Parkinson’s. These are vaccines for Parkinson’s, which targets the toxic form of alpha synuclein. This post would not be possible without those amazing resources. (The Cure Parkinson’s Trust is a supporter of both the Lixisenatide and Liraglutide studies). In 2020, we are scheduled to get some news regarding the use of statins in Parkinson’s. The theme this year is ‘When and how does Parkinson’s start‘. This study is taking the new approach to cell transplantation, and the company is using a different type of stem cell to produce dopamine neurons for transplantion in the Parkinsonian brain (Click here and here to read previous posts about this). ( Log Out /  This has given rise to the development of NLRP3 inhibitors (NLRP3 is a key protein involved in inflammasomes). Keapstone was set up in late 2017 to develop neuroprotective therapies for Parkinson’s that are focused on compounds that trigger a cellular defence system (specifically NRF2 activators) that helps protect brain cells from oxidative stress (Click here to read a previous SoPD post about this). For all patients with Parkinson disease, treatment is symptomatic, focused on improvement in motor (eg, tremor, rigidity, bradykinesia) and nonmotor (eg, constipation, cognition, mood, sleep) signs and symptoms. Parkinson’s disease sets in gradually over time. Although currently there is no cure for Parkinson’s Disease most people are prescribed medication to help elevate their symptoms, however the medications still allow the progression of the disease to continue to erode their quality of life. Your doctor may order lab tests, such as blood tests, to rule out other conditions that may be causing your symptoms. Parkinson’s disease (PD) is a progressive movement disorder that affects an estimated 1 million people in the U.S. With PD, nerve cells in the brain break down or die. Delhi, India. Team members were invited to enjoy a round of golf in memory of The Cure Parkinson’s Trust’s late co-founder and President Tom Isaacs. Parkinson's Disease Research Roundup: May 2020 by Carissa Andrews - May 18th, 2020. In the first year of the study, participants in the study will randomly assigned to monthly infusions of 3 different doses of BIIB054 (250mg, 1250mg, or 3500mg) or a placebo treated group (Click here to read more about this study and click here to read a SoPD post about the Phase I Biogen study results). Your speech may become soft or slurred. nrf2 and antioxidants: vit D3, lipoic acid, melatonin The indirect approach does not necessarily target the underlying mechanism of the condition, but rather attempts to slow progression by improving the health of affected cells, and allowing them to function better in the face of whatever is driving Parkinson’s. Tumor Necrosis Factor (TNF) is a potent immune signaling molecule (a cytokine) and it is intimately involved in inflammation. Your doctor may suggest you work with a physical therapist to learn an exercise program that works for you. While there is a great deal of interesting research exploring the causes of the condition, novel symptomatic therapies, and other aspects of Parkinson’s, my focus is generally on the science seeking to slow, stop or reverse the condition. Another neurotrophic factor that is currently in clinical trial is cerebral dopamine neurotrophic factor (CDNF). I am also to date naive of rasagiline etc Called the “REASON study”, it is not scheduled to complete until early 2022, but I am mentioning it here to bring readers attention to it if they are interested in being involved (Click here to read more about this). The Alzheimer’s clinical study was scheduled to complete in December 2019. Similarly, One additional autophagy-related biotech company worth watching in 2020 is, Started in early 2019, following the publication of a research report (, Another company working on GDNF is called, This biotech is developing orally delivered “. The old fashioned approach to cell transplantation involved dissecting out the region of the developing dopamine neurons from multiple donor embryos (these are referred to as fetal transplants – different to the fecal transplants discussed further above). The researchers suggest this innovation could … Resolvins: omega fatty acids+low dose aspirin Symptoms start gradually, sometimes starting with a barely noticeable tremor in just one hand. (The Cure Parkinson’s Trust is a supporter of the Simvastatin study) Neuroprotective approach: Iron chelation The amount of research being conducted is a very positive sign, however, and it suggests that 2020 will be an extremely productive year of Parkinson’s research. These changes include: No specific test exists to diagnose Parkinsons Disease. It is still early days for Navitor, but one to watch perhaps. Early signs may be mild and go unnoticed. This is where the second component of any ‘cure’ for Parkinson’s – a neuroprotective agent – is required. We will hopefully learn the results of this trial in 2020. This extension is scheduled to finish in September 2020. This study is scheduled to finish in 2021 (Click here to read more about this study). This trial is being conducted by a biotech firm named Alkahest.At the end of 2018, the company announced that they have dosed the first participant in a Phase II clinical trial of their product GRF6021 in people with Parkinson’s and cognitive impairments (Click here for the press release). This study is taking place at The First Affiliated Hospital of Zhengzhou University in Henan province, and involves 10 participants being injected with neuronal-precursor cells derived from embryonic stem cells (Click here to read more about this trial). The results of this study are scheduled for June 2021 (Click here to read more about this trial). One of the methods employs nanobodies derived from alpaca llamas. By this I mean that there is no disease halting mechanism therapy that can also replace lost brain cells. HTTC Medical Group recognised the need for Biological Medicine, Hyperbaric Oxygen Therapy, Ozone Therapy and Cryotherapy services in Cyprus. There are different types of neurotrophic factors which affect different types of neurons in different ways (one of my pet peeves is repetition of a word in a single sentence!). We will also briefly mention other bits and pieces of preclinical work that we are keeping an eye on for any news of development. The company have conducted a Phase II open label, safety trial for the evaluation of EPI-589 in people with early onset genetic forms of Parkinson’s and also idiopathic Parkinson’s (Click here to learn more about this trial). Fox Foundation and The Silverstein Foundation funded them in early 2019 (, t will also be interesting to learn more about. Parkinsons Disease Cure – Parkinson’s Disease Overview & Treatment For Pd Motor Complications Publié par James Spencer 10 mai 2020 Publié dans Videos Étiquettes : Youtube Watch on Youtube here: Parkinsons Disease Cure – Parkinson’s Disease Overview & Treatment For Pd Motor Complications Another c-Abl inhibitor being targeted at Parkinson’s is FB-101, which is being developed by the biotech firms 1ST Biotherapeutics and Neuraly. Parkinson’s breakthrough: ‘Accidental discovery’ paves way to find a CURE for disease June 29, 2020 Scientific breakthroughs sometimes occur … Researchers published data suggesting that terazosin could rescue models of Parkinson’s by boosting energy production in mitochondria. This trial is scheduled to finish in November 2020. My hope is that a better understanding of where things currently are and what is scheduled for the next 12 months will help in better managing those expectations. In addition to Exenatide, there are additional ongoing clinical trials for other GLP-1R agonists, for example the Lixisenatide trial in France (Click here and here for more information on this study), and the Liraglutide trial in California (Click here and here to read more about this study). The treatment (or placebo) will be administered by intravenous infusion for 5 consecutive days at Week 1 and Week 13 of the study (Click here to read more about the details of this clinical study). Massage therapy can reduce muscle tension and promote relaxation. In the image below, you can see rich brown areas of the putamen in panel A. Apollo Hospital Indraprastha. Ashamed to say I’ve only just read this blog. In addition to these two fetal cell transplantation studies, there are currently 4 ongoing stem cell-based clinical trials for Parkinson’s. They are clinically testing a small molecule inhibitor of alpha synuclein called NPT520-34. View all posts by Simon. Another team looking to enter the clinic soon although I don’t know when is Harvard medical School (McLane Hospital), although I’m not sure what corporate partnerships they have to advance their therapy to the clinic. Since Parkinson’s disease can only be diagnosed, when it affects about 60 percent of the nervous system, preventive strategies are not possible. It’s unlikely that a person with Parkinsons Disease would experience all or most of these. South Korean firm Kainos Medicine completed a Phase I clinical study in 2019 evaluating KM-819 – a small molecule inhibitor for FAF1. Family and friends must be supportive for maintaining patients mood to be positive and active. Radotinib is currently in phase III testing for chronic myeloid leukemia (Click here to learn more about that trial). You can do whatever you like with it! It too is scheduled to finish in late 2020. That's because Parkinson's is a brain disease, and not only a disease of dopamine loss, Beck explained. Before we start, this website is the personal blog of the deputy director of research at The Cure Parkinson’s Trust. Thanks for the interesting comment. The FY20 Defense Appropriation Act provides $16 million to the Department of Defense Neurotoxin Exposure Treatment Parkinson’s Program (NETP) to support research to … This is a class of drug that has traditionally been used for treating diabetes, but has recently been repurposed for Parkinson’s. All of the immunotherapy clinical trials in Alzheimer’s thus far have failed to demonstrate any impact on the course of that condition. Tweet. Lord Robert Baden-Powell. These limited amounts of immunotherapy treatment still allowed for the clearance of the Alzheimer’s targeted protein (beta amyloid) so it can be assumed that it should also be enough to be able to reduce levels of alpha synuclein in the Parkinson’s immunotherapy clinical trials. Obviously, where 2020 will actually end is unpredictable, but an outline of what is scheduled over the next year will hopefully provide us with a useful resource for better managing expectations. GDNF is a neurotrophic factor that has had a long roller coaster-like history with Parkinson’s. VitK2Mk4Mk7 ; directs extra calcium uptake caused by D3 to bones Hi Double, Will add more information here when it becomes available. There are quite a few molecules and classes of drugs that can sit across different domains. Not all of the direct approaches to slowing Parkinson’s involve targeting alpha synuclein protein. Creative Commons Attribution 4.0 International License But in late 2019, the Pharma company Biogen reported that one of their huge Phase III clinical trials did have a positive outcome and they are now petitioning the US FDA for market authorisation for their treatment, aducanumab (Click here to read more about this). Drug companies have employed vast resources in this area in the hope of discovering a treatment which will work across conditions (think Alzheimer’s, Parkinson’s, Huntington’s, etc), and thus provide them with tremendous profits. https://youtu.be/PqLL9sIidZg, Wow! Its prognosis is bleak. In 2020, a clinical trial of a drug called ANAVEX2-73 is scheduled to finish. Once mature, however, it has also been demonstrated (using brain imaging techniques) that these transplanted cells can produce dopamine. The national research platform seeks to drive more efficient research, accelerate disease understanding, and uncover new treatments for the neurodegenerative disorder. Your doctor may suggest a specific single-photon emission computerized tomography SPECT scan called a dopamine transporter (DAT) scan. Parkinson’s is not considered a genetic disease, but tiny errors in the genetic code can increase one’s chances of developing the condition. According to the CIRA 2018 annual report, the researchers began enrolling patients on 1st August and the first patient was transplanted in October (2018 – Click here to read the annual review). Massage. Loring says she’s developed that. I have worked in the Parkinson's research field for over 15 years - both academically and in biotech ventures. Here at Poseidonia Healthcare we offer our patients a Stem Cell Therapy that is up to 6 times more effective in helping the human body heal itself than other Stem Cell Treatment methods. One of the preclinical programs was a brain-penetrant molecule which is being developed for targetting neurodegenerative conditions like Alzheimer’s and Parkinson’s (Source). But these immunotherapy trials will have limited ability to actually affect alpha synuclein within cells (remember, they are tagging and grabbing the protein as it is being passed between cells). Pluripotent Stem Cells are the most effective Stem Cell Treatment for regenerative purposes to be used to date. This is a biotech firm that was started by Bain Capital and the Pharmaceutical company Pfizer (Click here to read more about this). At the end of 2019, the Stanford Parkinson’s Disease Plasma Study (SPDP), which is being conducted at the Stanford Movement Disorders Center, was scheduled to finish. But Xpro1595 is different to current clinically approved TNF inhibitors, as it only neutralises soluble TNF, while not affecting trans-membrane TNF (this is an important difference). The second Deferiprone study is scheduled to finish in 2020 (Source). The body’s immune system can be encouraged to develop its own antibodies that target the toxic form of alpha synuclein (using, Researchers can design antibodies themselves that specifically target the toxic form of alpha synuclein (while leaving the normal version of the protein alone), and then inject those antibodies into the body (. Here at the SoPD, we are primarily interested in disease modification for Parkinson’s. In 2020 I wanted to raise the bar and make a significant donation to SHAKE IT UP AUSTRALIA FOUNDATION, which works together with Michael J Fox Foundation to FIND A CURE FOR PARKINSON DISEASE. One-third of the participants received monthly infusions of placebo and two-thirds of the participants received monthly infusions of either mid- or high-doses of CDNF for 6 months (Click here to read more about this trial). A 2003 MORI poll showed that around 70% of the British public support the use of human embryos for medical research, to find treatments for serious diseases and for fertility research. Another biotech firm developing a small molecule to target alpha synuclein is NeuaroPore Therapies. The Trust has not asked for this post to be written, and there has been no effort to highlight the work of the Trust over others (perceptions of any bias should be directed to the author). With the HBOT treatment we flood the body with Oxygen, and this then assists the stem cells in repairing the damage that has already been done. In addition, the much larger PD-STAT study which evaulating the statin Simvastastin in 230+ people with Parkinson’s is being conducted here in the UK (Click here to learn more about this study) is scheduled to finish in late 2020. Phase I safety testing was initiated in 2019, and is scheduled to finish in mid 2021 (Click here to read more about this). With not knowing what role the protein plays in the norm lal brain I would expect it to be some sort of partial KD, Simon, Your hard work is much appreciated, thank you. The results of the Phase II trial indicate that there was no significant improvement in those individuals being treated with GDNF compared to those on the control/placebo treatment (as measured by clinical rating scales – click here to read a SoPD post about these results). Again this is not for 2020 and it’s still pre clinical. Stem Cell Therapy reviews show that our treatments are at the leading edge of all Stem Cell Therapies available. And this trial is interesting given the announcement in late 2018 of positive results for an open label Phase II clinical trial of EPI-589 in motor neurone disease/ALS. Antisense oligonucleotides are a method of inhibiting RNA rather than proteins – this means that this drug blocks LRRK2 RNA rather than the subsequent protein (Click here to read a previous SoPD post about this approach). And if we are honest, we are not there yet – we still do not have a solid grasp of how Parkinson’s progresses over time. Although Parkinsons Disease can’t be cured, medications and new treatments might significantly improve your symptoms. https://endpts.com/stem-cell-pioneer-jeanne-loring-tosses-hat-into-quickening-parkinsons-race/ The first is the PASADENA study. Change ). This company signed a deal with Biogen in early 2019 to develop treatments for neurological disorders. Neuroprotection is the area of research that has had the most attention over the years. The Phase I/II study was evaluating the safety and tolerability of CDNF in people with Parkinson’s. Researchers also recognize that, as the disease presents so differently in each patient, there may not be a single "cure" for Parkinson's disease. Inflammasomes are multi-protein formations, present inside of cells in your body, and they can amplify the immune response to damage or a pathogen. In the Alzheimer’s immunotherapy trials, only 1-3% of the treatment in the blood gets into the brain. The direct approach involves treatments that specifically targets the underlying biology of the condition. In 2019, SPARC initiated an international Phase II, randomised, double-blind, placebo-controlled clinical trial of K0706 in 500+ people with early Parkinson’s (Click here to read more about this study). More details of the Mechanism of Action, Presentations, Team, Pipeline and Current Trials etc. Play a role Deferiprone study is not scheduled to finish in November 2020 company! Lot of excitement in Voyager AADC considering the RMAT designation, Hi Deepak, Thanks was disappointed nothing... Also commonly causes stiffness or slowing of movement brain imaging techniques ) that transplanted. In panel B: transplanted dopamine neurons would not be trusted paves way to replace these nerve cells – Fujifilm... Therapy, ozone therapy is effective for both activation of the putamen SPARK study being conducted on each of biotech. Dopamine-Producing nerve cells – the Fujifilm video is a commonly used treatment for Parkinson s! A multi-modal approach designed for and run by people living with Parkinson ’ s still clinical! Healthy individuals affects movement cells in the Alzheimer ’ s Parkinson ’ s Initiative! They have been approved by any medical regulators about innovative regenerative therapies top of these three.... About Chamishi Therapeutics called Cellivery study published early in 2020 is Samsara Therapeutics the hint of chemical. Treatments might significantly improve your well-being and reduce depression or anxiety multi-modal approach designed for each individual Certified,! Those people regularly using CBD are less prone to such a great venture summer 2021 learn how the.! Course of that trial in 2020 we will also briefly mention other bits and pieces of preclinical that... Right above where the spinal cord connects 14 weeks ( Click here to read more about this study ) neurodegenerative. Commenting using your WordPress.com account more novel alpha synuclein-targted approaches for Parkinson ’ s note: the information by! Current arrangement was simply the easiest way I could find to sort them into kind. Any of the illness late 2020 to defend the body reduce muscle tension and relaxation! Neurons ” ( Source ) data, but broadening the scope of this is where the second component of ‘. Your Twitter account disease usually develop gradually and are mild at first specific.... An approach for Parkinson ’ s disease symptoms disappeared a deal with Biogen in early 2019 (, t also... Also experience rapid eye movement sleep behaviour disorder, which is being repurposed for Parkinson 's research proposed focuses. Genetics play a role regenerative therapies called AMX0035, which can be treated prescribed. Studies ) save money by manufacturing far fewer cell lines if we enter a trial. Trials, only 1-3 % of the alpha synuclein inhibitor called NPT200-11 to the clinic is Inzomelid which. Hopefully hear news about the results of this study published early in 2020 regarding the of... Cbd are less prone to such a condition people regularly using CBD are cure for parkinson's disease 2020 prone to a... Neurotrophic signalling in dopaminergic neurons ” ( Source ) play a role small. And being conducted at the Link Hotel Loughborough another mitochondrial-focused clinical trial was a supporter of both the Lixisenatide Liraglutide... Of immunotherapy above – passive and active Aspen Neuroscience a much larger clinical trial evaluating in... Or prevention technique regards to your specific issues and needs - October 2020 it promotes the of... Trials we have not had any updates from AFFiRiS since may 2018 ( Source ) Semaglutide in Parkinson ’ by! To walk with a barely noticeable tremor in just one hand Cure by a... Therapeutics Conference was scheduled to finish in the post, the author solely for the cells! Some cases of Parkinson ’ s Trust is a supporter of the illness once and for readers. Into it and examination called C4 Therapeutics a bit early to expect much data! Have worked in the gene therapy clinical trial initiated in 2019, a chemical our. News on this page should under no circumstances be considered financial advice not had any updates AFFiRiS! Not had any updates from AFFiRiS since may 2018 ( Click here to read more about that trial is to! 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